VDM provides a versatile runtime application exclusion feature, enabling specific applications to bypass VDM control when required. This can be accomplished in two ways:

1. On-the-fly Exclusion: Use the Ctrl+Alt key combination while maximizing a window to exclude it temporarily.
2. Persistent Exclusion: Configure VDM to exclude applications persistently during their runtime.

For scenarios where stricter exclusion measures are necessary—such as in video games with advanced memory protection or anti-cheat systems that only allow whitelisted applications—VDM supports driver-level exclusions. This approach ensures compatibility by bypassing VDM control at the driver level, avoiding potential conflicts or errors.

VDM includes a dedicated utility to configure these driver-level exclusions, offering a seamless solution for applications requiring enhanced runtime compatibility.